Hydrogen-bonding interactions drive oligosquaramides of different lengths to fold into hairpin-like structures both in nonprotic and protic solvents. These compounds are useful preorganized precursors in macrocyclization reactions.
![Efficient macrocyclisation of preorganized palindromic oligosquaramides](https://www.iciq.org/wp-content/uploads/2014/03/Efficient-macrocyclisation_eng_noticies_articles_2006_11.gif)
Hydrogen-bonding interactions drive oligosquaramides of different lengths to fold into hairpin-like structures both in nonprotic and protic solvents. These compounds are useful preorganized precursors in macrocyclization reactions.