Míriam Sau, PhD student under the supervision of Profs. Miquel A. Pericàs and Rubén Martín, has defended her PhD Thesis entitled ‘From Click Chemistry to Catalytic Cleavage of Unstrained C-C Bonds’ (assigned to the Organic and Analytical Chemistry Department of the Universitat Rovira i Virgili) publicly on July 21st at the ICIQ auditorium.

The members of the evaluation committee were: Prof. Albert Moyano Baldoire (Universitat de Barcelona), Prof. María Elena Fernández Gutiérrez (Universitat Rovira i Virgili) and Prof. Florenci González Adelantado (Universitat Jaume I).

 

Abstract:

In this PhD thesis, different methodologies have been used for the synthesis of different small molecules bearing interesting scaffolds for research. Specifically, a Cu-free 1,3-dipolar cycloaddition reaction was developed using t-BuOH/H₂O under microwave irradiation for the synthesis of triazoles fused to seven membered rings. Additionally, we have implemented a catalytic functionalization of unstrained C–C bonds of 1,2-amino acids, resulting in a formal b-arylation of aldehydic counterparts.