Abstract: Structure sensitivity is one of the key parameters that needs to be controlled to obtain atomistic design of catalysts. By means of density functional theory we have analyzed the synthesis of vinyl acetate from acetic acid, ethylene, and oxygen in several local configurations of Pd dimers on two gold surfaces (111) and (100). We have found that the most active configuration shows the best compromise between the sufficient adsorption of the reactants without poisoning the Pd template and a low barrier for the rate determining step.