A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.
![Synthesis of heavily substituted 1,2-amino alcohols in enantiomerically pure form](https://www.iciq.org/wp-content/uploads/2014/03/Synthesis-of-heavily_eng_noticies_articles_2005_16.gif)