Publications

Synthesis of Ecteinascidin 743 Analogues from Cyanosafracin B: Isolation of a Kinetically Stable Quinonimine Tautomer of a 5-Hydroxyindole

P. A. Ceballos, M. Pérez, C. Cuevas, A. Francesch, I. Manzanares, A. M. Echavarren

Eur. J. Org. Chem. 2006, 1926-1933.

Phthalimido derivatives of cyanosafracin B have been synthesized as analogues of the antitumor agent ecteinascidin 743. As part of this study, a quinoneimine has been prepared, which is a kinetically stable tautomer of a 5-hydroxyindole. This quinoneimine tautomer is stable under acidic and mild basic conditions.

$Synthesis of Ecteinascidin analogues from Cyanosafracin B: isolation of a kinetically stable quinonimine tautomer of a 5-hydroxyindole$

Research