Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.
![Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes](https://www.iciq.org/wp-content/uploads/2014/03/Stabilization-of-G-quadruplex_eng_noticies_articles_2006_53.gif)