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Intranet

Site-Selective Defluorinative sp3 C–H Alkylation of Secondary Amides

A site-selective defluorinative sp3 C–H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

Yue, W. J.; Day, C. S.; Martin, R.

J. Am. Chem. Soc. 2021, 143 (17), 6395–6400
DOI: 10.1021/jacs.1c03126

Associated ICIQ research group/s:

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