A continuous flow setup has been implemented for the enantioselective production of a library of pyranonaphthoquinones. This was possible through a sequential two-step process involving a squaramide-catalyzed Michael reaction and oxa-Michael cyclization. A key factor for the success of this methodology was the development of a new, cost-effective polystyrene-supported squaramide.
L. Osorio-Planes, C. Rodríguez-Escrich, M. A. Pericàs
Catal. Sci. Technol. 2016, 6, 4686-4689
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