Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
In our on-going program targeting anti-pox activity, the synthesis of various acyclic nucleoside phosphonates is described using olefin cross-metathesis reaction and Pd(0)-mediated alkylation at the C5-position of the uracil moiety.
H. Kumamoto, D. Topalis, J. Broggi, U. Pradere, V. Roy, S. Berteina-Raboin, S. P. Nolan, D. Deville-Bonne, G. Andrei, R. Snoeck, D. Garin, J.-M. Crance, L. A. Agrofoglio
Tetrahedron 2008, 64, 3517-3526
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