In our on-going program targeting anti-pox activity, the synthesis of various acyclic nucleoside phosphonates is described using olefin cross-metathesis reaction and Pd(0)-mediated alkylation at the C5-position of the uracil moiety.
![Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis](https://www.iciq.org/wp-content/uploads/2014/03/Preparation-of-acyclo_eng_noticies_articles_2008_64.jpg)
In our on-going program targeting anti-pox activity, the synthesis of various acyclic nucleoside phosphonates is described using olefin cross-metathesis reaction and Pd(0)-mediated alkylation at the C5-position of the uracil moiety.