Nickel-Catalyzed Ipso/Ortho Difunctionalization of Aryl Bromides with Alkynes and Alkyl Bromides via a Vinyl-to-Aryl 1,4-Hydride Shift

Polysubstituted arenes are ubiquitous structures in a myriad of medicinal agents and complex molecules. Herein, we report a new catalytic blueprint that merges the modularity of nickel catalysis for bond formation with the ability to enable a rather elusive 1,4-hydride shift at arene sp2 C–H sites, thus allowing access to ipso/ortho-difunctionalized arenes from readily available aryl halides under mild conditions and exquisite selectivity profile.

He, Y.; Börjesson, M.; Song, H.; Xue, Y.; Zeng, D.; Martin, R.; Zhu, S.

J. Am. Chem. Soc. 2021, 143 (48), 20064–20070
DOI: 10.1021/jacs.1c10368

Associated ICIQ research group/s:

  • RESEARCH GROUP/S
    Prof. Ruben Martin
Go to the journal
  • SHARE

Let's create a brighter future

Join our team to work with renowned researchers, tackle groundbreaking
projects and contribute to meaningful scientific advancements

Join us!
Board of Trustees:
Member of:
Accredited with:
With the support of: