A user-friendly Ni-catalyzed reductive carboxylation of benzylic C−N bonds with CO2 is described. This procedure outperforms state-of-the-art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or β-hydride elimination, thus leading to new knowledge in cross-electrophile reactions.
Nickel-Catalyzed Carboxylation of Benzylic C-N Bonds with CO2
Angew. Chem. Int. Ed. 2016, 55, 5053-5057.
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