An efficient Ni-catalyzed protocol for the reductive cleavage of inert C-O bonds has been developed. The method is characterized by its simplicity and wide scope, thereby allowing the use of aryl ethers as easily removable directing groups in organic synthesis.
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![Ni-catalyzed reduction of inert C-O bonds: A new strategy for using aryl ethers as easily removable directing groups](https://www.iciq.org/wp-content/uploads/2014/03/Ni-catalyzed-reduction_Ruben.gif)