A novel Ni-catalyzed reductive amidation of C(sp2)-O and C(sp3)-O electrophiles with isocyanates is described. This umpolung reaction allows for an unconventional preparation of benzamides using simple starting materials and easy-to-handle Ni catalysts.
![Ni-Catalyzed Direct Reductive Amidation via C-O bond Cleavage](https://www.iciq.org/wp-content/uploads/2014/06/Ni-Catalyzed-Direct-Reductive_14_JACS_RMartin_7253.gif)