The reaction of a bispropargyl bromide enediyne with several bis-NH-sulfonamide nucleophiles permits the easy synthesis of 14- and 19-membered macrocyclic enediynes. The new nitrogen-containing unsaturated macrocycles are fully characterized. The thermal reactivity of the new cyclic enediyne derivatives is investigated by means of differential scanning calorimetry (DSC).
![New unsaturated azamacrocyclic enediynes: Synthesis, structural analysis, and thermal behavior](https://www.iciq.org/wp-content/uploads/2014/03/New-unsaturated_eng_noticies_articles_2006_39.gif)