Three distinct aminocatalytic cascade reactions leading to enantiomerically pure spirocyclic benzofuranones have been devised, highlighting the ability of organocascade to generate high degrees of stereochemical and architectural complexity in a single chemical transformation.
![Multiple approaches to enantiopure spirocyclic benzofuranones using organocatalytic cascade reactions](https://www.iciq.org/wp-content/uploads/2014/03/Multiple-approaches_233.gif)