The mechanistic study of the palladium-catalyzed Suzuki-Miyaura cross-coupling between bromophenylpyridine compounds and phenylboronic acid led to the NMR identification of a transient intermediate in the transmetalation step. This species was identified by DFT calculations as a [Pd{Ph-B(OH)3–}{C5H2RN}(PR3)2] complex, containing a boronate ligand coordinated through an oxygen group to the metal center. The fitting of this intermediate within recent mechanistic proposals on the mechanism of transmetalation is discussed.
![Mechanistic insights into the transmetalation step of a Suzuki-Miyaura reaction of 2(4)-bromopyridines: Characterization of an intermediate](https://www.iciq.org/wp-content/uploads/2014/03/Mechanistic-insights-into_eng_noticies_articles_2008_62.jpg)