Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes

A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.

Jankins, T.; Martin-Montero, R.; Cooper, P.; Martin, R.; Engle, K.

J. Am. Chem. Soc. 2021, 143 (37), 14981–14986
DOI: 10.1021/jacs.1c07162

Associated ICIQ research group/s:

  • RESEARCH GROUP/S
    Prof. Ruben Martin
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