Fluoroform-derived CuCF3 for low-cost, simple, efficient, and safe trifluoromethylation of aryl boronic acids in air

Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF₃ in DMF in non-dried air. The reaction occurs under mild conditions (1?atm, room temperature), exhibits unprecedented functional-group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield.