A homologous series of N,N,N′,N′-tetramethylalkyl-N,N′-dioxides is used to probe the level of guest induced fit attainable in the assembly of a dimeric capsule based on tetraurea benzyl calix[4]pyrrole components. A sensible enhancement of the capsule’s volume was observed in response to guest size for n = 2, 3, and 4. In turn, larger guests adopted folded conformations to adapt to the capsule’s dimensions.
![Exploring the self-assembly of polar dimeric capsules using molecular rulers](https://www.iciq.org/wp-content/uploads/2014/03/Exploring-the-self-assembly_5708.gif)