A methodology for the direct use of trimethylsilyl-protected alkynes in the copper(I)-mediated alkyne-azide cycloaddition reaction without the need of a previous deprotection step is reported. This methodology is selective for the trimethylsilyl in front of other silicon-based C(sp)-H protecting groups.
![Direct copper(I)-catalyzed cycloaddition of organic azides with TMS-protected alkynes](https://www.iciq.org/wp-content/uploads/2014/03/Direct-copperI-catalyzed_1873.jpg)