Chiral calixarene-based diphosphite ligands 3a–d have been obtained via lower-rim functionalisation of the p-tert-butylcalix[4]arene core. High enantiomeric excesses (up to 94 %) and good activities were obtained in the rhodium-catalyzed asymmetric hydrogenation of prochiral olefins withTADDOL-containing diphosphites 3c,d. This is the first example of chiral calix[4]arene-modified ligands that induce high enantioselectivity in metal-catalysed asymmetric reactions.
A. Marson, Z. Freixa, P. C. J. Kamer, P. W. N. M. van Leeuwen
Eur. J. Inorg. Chem. 2007, 4587-4591
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