A simple and direct protocol is reported for the synthesis of the first non-symmetrically substituted 1,3-alternate conformers of calix[4]arenes by selective mono-deacylation of a tribenzoyl precursor under basic conditions, followed by dialkylation.
![A fast access to non-symmetrically substituted 1,3-alternate conformers of calix[4]arenes](https://www.iciq.org/wp-content/uploads/2014/03/A-fast-access-to-non-symmetrically-substituted-13-alternate-conformers-of-calix4arenes_eng_noticies_articles_2004_12.gif)