A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres

The synthesis and chiral resolution of a dissymmetric tetraurea-calix[4]pyrrole/tetraurea-calix[4]arene molecular capsule with two hemispheres mechanically locked is described. The assembly features a bis-[2]catenated topology and shows reversible molecular co-encapsulation of two different neutral molecules or two oppositely charged ions.