Research on kinetic resolution of vinyl sulfoxides highlighted in Synfacts

A paper published by Prof. Vidal research group in Organic Letters has been highlighted in Synfacts, Vol 11, Issue 11, 1184. Synfacts selects the most significants results on synthetic organic chemistry that appear in the literature considered as the future trends in synthetic chemistry.

Abstract: Enantiopure sulfoxides are valuable precursors of organosulfur compounds with broad application in organic and pharmaceutical chemistry. An unprecedented strategy for obtaining highly enantioenriched sulfoxides based on a hydrogenative kinetic resolution using Rh-complexes of phosphine-phosphite ligands as catalysts is reported. After optimization, highly efficient conditions for the kinetic resolution of racemic sulfoxides have been identified. This methodology has been applied to a set of racemic aralkyl or aryl vinyl sulfoxides and allowed the isolation of both recovered and reduced products in excellent yields and enantioselectivities (up to 99% and 97% ee, respectively; 16 examples).

Hydrogenative Kinetic Resolution of Vinyl Sulfoxides
J. R. Lao, H. Fernández-Pérez, A. Vidal-Ferran
Org. Lett., 2015, 17, 4114-4117

15 OL AVF 4114

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