A paper published by Prof. Martin research group in Angewandte Chemie International Edition has been highlighted in Synfacts, Vol 11, Issue 4, 389. Synfacts selects the most significants results on synthetic organic chemistry that appear in the literature considered as the future trends in synthetic chemistry.

The paper reports the first enantioselective C—C bond formation through C—O bond cleavage using aryl ester counterparts. This method is characterized by its wide substrate scope and results in the formation of quaternary stereogenic centers with high yields and asymmetric induction.

 

Nickel-Catalyzed Enantioselective C—C Bond Formation through C—O C(sp2)-O Cleavage in Aryl Esters
J. Cornella, E. P. Jackson, R. Martin
Angew. Chem. Int. Ed., 2015, 54, 4075-4078