Ni-Catalyzed Oxygen Transfer from N2O onto sp3-Hybridized Carbons
Herein we disclose a catalytic synthesis of cycloalkanols that harnesses the potential of N2O as an oxygen transfer agent onto sp3-hybridized carbons. The protocol is distinguished by its mild conditions and wide substrate scope, thus offering an opportunity to access carbocyclic compounds from simple precursors even in an enantioselective manner. Preliminary mechanistic studies suggest that the oxygen insertion event occurs at an alkylnickel species and that N2O is the O transfer reagent.
Ni, S.; Le Vaillant, F.; Mateos-Calbet, A.; Martin, R.; Cornella, J.
J. Am. Chem. Soc 2022, 144 (40), 18223–18228
DOI:
10.1021/jacs.2c06227
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