New Unsaturated Azamacrocyclic Enediynes: Synthesis, Structural Analysis, and Thermal Behavior

The reaction of a bispropargyl bromide enediyne with several bis-NH-sulfonamide nucleophiles permits the easy synthesis of 14- and 19-membered macrocyclic enediynes. The new nitrogen-containing unsaturated macrocycles are fully characterized. The thermal reactivity of the new cyclic enediyne derivatives is investigated by means of differential scanning calorimetry (DSC).