Following his studies on the intermolecular diamination reactions of alkenes through Pd catalysis, Kilian Muñiz and colleagues have now extended this C-N bond forming reaction to the direct palladium-catalysed intermolecular C-H amidation of several substrates.

They have identified NFSI (N-fluorobis(phenylsulfonyl)-imide), a commercially available oxidant, as both the oxidant and the nitrogen source for the Pd-catalyzed intermolecular sequence of the C-H activation and amidation of methyl groups.

They also provide mechanistic studies that suggest the involvement of a monomeric Pd (IV) intermediate also present in the C-N bond formation of their previous studies on the intermolecular diamination of alkenes.

This communication has been chosen as a “Hot Paper“ by the Editors of Angew. Chem. Int. Ed. for its importance in a rapidly evolving field of high current interest.

Read the paper here.

Dr. álvaro Iglesias, Prof. Dr. Rosana álvarez,Prof. Dr. ángel R. de Lera, Prof. Dr. Kilian Muñiz

DOI: 10.1002/anie.201108351