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Melchiorre's paper: Significant contribution to Angewandte's 2011 Impact Factor

The generation of all-carbon quaternary stereocenters and the construction of highly strained polycyclic structures is one of the greatest challenges for organic chemists. Both are structural features of many natural products and medicinal compounds.

The spirocyclic oxindole core is an example of these challenging structures.

In this paper, Paolo Melchiorre and his team develop a direct one-step synthesis of spirocyclic oxindoles by asymmetric organocascade catalysis. They use two different organocatalysts that activate carbonyl compounds, such as ketones and aldehydes, with extraordinary levels of stereocontrol.

If you want to find out about those catalysts read the article here and to see the list of articles that, together with this one, have contributed the most to Angewandte’s 2011 impact factor go here.

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Giorgio Bencivenni, Li-Yuan Wu, Andrea Mazzanti, Berardino Giannichi, Fabio Pesciaioli, Mao-Ping Song, Giuseppe Bartoli, Paolo Melchiorre

Angew. Chem. Int. Ed. 2009, vol. 48, pp. 7200–7203