Enantioselective synthesis of (-)-Nardoaristolone B succeeds
A paper published by Prof. Echavarren research group in Organic Letters has been highlighted in Synfacts, vol 11, issue 4 (351). Synfacts selects the most significant results on synthetic organic chemistry that appear in the literature considered as the future trends in synthetic chemistry.
The paper deals with the first enantioselective total synthesis of (-)-nardoaristolone B. The reaction is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.
Enantioselective Total Synthesis of (-)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
A. Homs, M. E. Muratore, A. M. Echavarren
Org. Lett., 2015, 17, 461-463
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24-10-2024 
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