Site-Selective and Enantioselective C-H Functionalization

The development of practical methods for site selective C-H functionalization is of intense current interest. This presentation will describe a collaborative approach towards achieving new C-H functionalization strategies and our recent advances in the C-H insertion chemistry of donor/acceptor-substituted carbenoids. A series of chiral dirhodium catalysts have been developed for this chemistry and they are capable of controlling which C-H bond is functionalized.^1,2 The application of these new synthetic strategies to the synthesis of natural products and pharmaceutical targets will be described.