S,O-Ligand-promoted Pd-catalyzed C-H Functionalization Reactions

Metal-catalyzed C-H functionalization has become a powerful synthetic tool to introduce complexity in organic molecules since no pre-functionalization of starting materials is required, reducing the number of synthetic steps, the cost of the process and the waste formation, all key aspects for the development of sustainable synthetic routes. However, the low reactivity and selectivity observed in many of these processes hamper the broad implementation of this strategy in organic laboratories. To unlock the full potential of metal-catalyzed C-H functionalization, the discovery of new ligands capable of increasing the reactivity and controlling the selectivity is of central importance. In this communication, I will present the discovery of new type of S,O-ligands capable of promoting a variety of C-H functionalization reactions.