Amide Formation via Ni-Catalyzed Reductive Coupling Reactions with Isocyanates

The ubiquity of amides in biologically active molecules and synthetic materials continually prompts the design of novel methods for amide synthesis. This doctoral thesis focuses on the development of new Ni-catalyzed reductive protocols for the synthesis of amides via C–C bond formation. The methodologies developed herein start from different electrophiles in combination with isocyanates, which serve as amide synthons, to afford aliphatic amides or acrylamides under mild conditions and with high chemo- and regioselectivity.