Gold(I) Cavitands for the Assembly of Molecular Complexity

In this Doctoral Thesis, new families of both chiral and achiral gold(I)-cavitand complexes have been designed and prepared from resorcin[4]arene precursors. The achiral gold(I) complexes were applied in the cycloisomerization of 1,6-dienynes and led to uncovering of new selectivities. On the other hand, the chiral gold(I) cavitands allowed to develop a broad-scope enantioselective alkoxycyclization of 1,6-enynes, which was applied to the first total synthesis of (+)-mafaicheenamine C. New types of non-acceptor carbene precursors were also developed. These precursors allowed to carry out gold(I)-catalyzed decarbenations of persistent cyclopropanes, releasing polyaromatic units as driving force. Following this methodology, a variety of cyclopropanes were obtained upon release of naphthalene or phenanthrene. Finally, the ability of gold(I) complexes to construct polycyclic architectures was demonstrated by devising a novel approach for the synthesis of decalins by polyenyne cyclization of tetrasubstituted silyl enol ethers. The obtained decalins are key intermediates in the synthesis of the natural products.

—

According to the last information received from ICIQ’s safety department about the measures to prevent and contain COVID-19 at ICIQ, a total of 50 people is now the maximum capacity allowed in the Auditorium, so the Thesis Defense will be finally held in the Auditorium as well as through ZOOM platform too.

For those who prefer to follow the ceremony in a virtual format, please remember that you should register here.

If you are interested in attending in the Auditorium, please, fill in this registration form to be sure that we do not exceed the maximum capacity. (It will be assigned on a first-come/first served basis). We will confirm your acceptance through an e-mail as soon as possible after your registration.