Towards molecular medicine
In the health research area at ICIQ, different research groups are currently active in applying their research to introduce innovative solutions in the healthcare sector. In this area, ICIQ is engaged in developing advanced sensor technologies that can revolutionise medical diagnostics and monitoring, identify new therapeutic compounds targeting specific diseases, provide selective chemical transformations to pharmaceuticals and biologically- relevant entities, and study the interactions between chemicals and biological systems to enhance healthcare solutions.
Industry and markets
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Global health
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Pharmaceutical
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Sensors (diagnostics)
Solutions
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Chemical sensors
Development of sensors for the diagnostics of diseases and identification of pathogens based on the recognition of biological markers.
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Medicinal chemistry
Preparation of new molecular entities with biological activity, from its conceptualisation and modelisation to fit in the biological target, to improve its solubility, permeability and ADME properties; and discovery of new processes to incorporate new pharmacophores.
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Process chemistry studies
Support for regulatory filing and QbD tasks, development of more efficient routes, and improvement of drug properties through solid-state studies.
Projects and technologies
- ENRICH: Molecular receptors enrich methylated and acetylated peptides for ultra-sensitive proteomics to explore the hidden modified proteome in disease.
- Phase I clinical trial of a new antifibrinolytic agent (the compound CM-352) with an efficient synthesis route, aimed at the control of disabling and lethal hemorrhages.
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Research on new innovative drugs from the family of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of pain and inflammatory processes.
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BREAKthrough: Breaking the barrier – An integrated multidisciplinary approach to kill Gram-negative bacteria through existing antibiotics by making their outer membrane permeable.
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Development of biosensors for non-invasive continuous monitoring of health markers.
Chemical sensors:
• Potentiometric sensor for creatinine: renal health monitoring Licensed to Renalyse
Medicinal chemistry:
• Englerin derivatives for treatment of cancer Licensed to the National Institute of Health EEUU (NIH) and the National Cancer Institute (NCI) from USA.
• Epoxyazulene derivatives useful for treating cancer and diabetes Licensed to the National Institute of Health EEUU (NIH) and the National Cancer Institute (NCI) from USA.
Business & Innovation
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