Continuous organocatalytic flow synthesis of 2-substituted oxazolidinones using carbon dioxide
A polystyrene-supported 1,5,7-triazabicyclodec-5-ene (TBD) was used as a highly recyclable and stable catalyst for the conversion of epoxy amines into various 2-oxazolidone scaffolds. This approach combines the use of CO2 as an attractive, cheap and abundant C1 source with a halide-free, organocatalytic continuous flow approach to promote the efficient synthesis of a small library of pharmaceutically relevant 2-substituted oxazolidinones, including the known drug Toloxatone. A packed bed reactor containing the same batch of immobilized catalyst could be applied for the continuous synthesis of a series of heterocyclic products over a two week period without significant changes in catalytic activity.
Zanda, N.; Zhou, L.; Alza, E.; Kleij, A. W.; Pericas, M. A.
Green Chem. 2022
DOI:
10.1039/D2GC00503D
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