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Synthesis of (+)-Schisanwilsonene A by Tandem Gold-Catalyzed Cyclization/1,5-Migration/Cyclopropanation

M. Gaydou, R.E. Miller, N. Delpont, J. Ceccon, A.M. Echavarren
Angew. Chem. Int. Ed. 2013, 52, 6396-6399.

Going (anti)viral: The first total synthesis of the antiviral (+)-schisanwilsonene?A has been completed using a fully stereoselective tandem cyclization/1,5-migration/intermolecular cyclopropanation. The key reaction sequence is catalyzed by gold.

Synthesis of (+)-Schisanwilsonene A by Tandem Gold-Catalyzed Cyclization/1,5-Migration/Cyclopropanation