Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.
![Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex](https://www.iciq.org/wp-content/uploads/2014/03/Stabilisation-of-human_4366.gif)
Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.