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Remote sp2 C–H Carboxylation via Catalytic 1,4-Ni Migration with CO2

Börjesson, M.; Janssen-Müller, D.; Sahoo, B.; Duan, Y.; Wang, X.; Martin, R.
J. Am. Chem. Soc. 2020, 142 (38), 16234–16239, DOI: 10.1021/jacs.0c08810.

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* Synfacts Highlights in Chemical Synthesis

A remote catalytic reductive sp2 C–H carboxylation of arenes with CO2 (1 bar) via 1,4-Ni migration is disclosed. This protocol constitutes the first catalytic 1,4-Ni migration reported to date, thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconventional new platform for incorporating electrophilic sites at remote sp2 C–H linkages.