Enantiopure trans-3-trifluoromethylsulfonylamino-4-silyloxypyrrolidines efficiently catalyse the asymmetric α-aminoxylation of aldehydes. At 1% catalyst loading (solvent-free conditions) or at 2% catalyst loading (acetonitrile solution) aldehydes are completely converted in short reaction times leading to α-aminoxylation products with very high (96-99%) enantioselectivity.
![A highly active organocatalyst for the asymmetric alpha-aminoxylation of aldehydes and alpha-hydroxylation of ketones](https://www.iciq.org/wp-content/uploads/2014/03/A-highly-active-organocatalyst_6164.gif)