The chemical inertness of abundant and commercially available alkyl chlorides precludes their widespread use as reactants in chemical transformations. In this work, we present a metallaphotoredox methodology to achieve the catalytic intramolecular reductive cyclization of unactivated alkyl chlorides with tethered alkenes. The cleavage of strong Csp3‐Cl bonds is mediated by a highly nucleophilic low‐valent cobalt or nickel intermediate generated via visible light photoredox reduction employing a copper photosensitizer. The high basicity and multidentate nature of the ligands are key to obtain efficient metal catalysts for the functionalization of unactivated alkyl chlorides
Claros, M.; Ungeheuer, F.; Franco, F.; Martin-Diaconescu, V.; Casitas, A.; Lloret-Fillol, J.
Angew. Chem. Int. Ed. 2019, 58 (15), 1869-1874
DOI:
10.1002/anie.201812702
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