Substituted benzolactones can be obtained in one step by a Pd-catalyzed ligand-accelerated C(sp3)H bond-activation/C(sp3)O bond-formation protocol. This step-economical approach enables the preparation of benzolactones with a wide variety of functional groups and different substitution patterns. The method is characterized by its simplicity and the avoidance of protecting groups.
P. Novák, A. Correa, J. Gallardo-Donaire, R. Martin
Angew. Chem. Int. Ed. 2011, 50, 12236-12239
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