An innovative approach to position‐selective polyhalogenation of aliphatic hydrocarbon bonds is presented. The reaction proceeded within the Hofmann‐Löffler manifold with amidyl radicals as the sole mediators to induce selective 1,5‐ and 1,6‐hydrogen‐atom transfer followed by halogenation. Multiple halogenation events of up to four innate C−H bond functionalizations were accomplished. The broad applicability of this new entry into polyhalogenation and the resulting synthetic possibilities were demonstrated for a total of 27 different examples including mixed halogenations.
E. Del-Castillo, M. D. Martínez, A. E. Bosnidou, T. Duhamel, C. Q. O'Broin, H. Zhang, E. C. Escudero‐Adán, M. Martínez‐Belmonte, K. Muñiz
CHEM-EUR J 2018, 24 (65), 17225-17229
DOI:
10.1002/chem.201804504
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