Hydrogen Bonded Squaramide-Based Foldable Module Induces Both β- and α-Turns in Hairpin Structures of α-Peptides is Water

A novel tertiary squaramido-based reverse-turn module SQ is reported, and its conformational properties are evaluated. This module is easily incorporated into a α-peptide sequence by conventional solid-phase peptide synthesis. The structure characterization of the hybrid squaramido-peptide 4 is described, showing that the turn segment induces the formation of hairpin structures in water through the formation of both αSQ- and βSQ-turns.

L. Martínez, G. Martorell, A. Sampedro, P. Ballester, A. Costa, C. Rotger

Org. Lett. 2015, 17, 2980-2983
DOI: Go to the journal

Associated ICIQ research group/s:

Go to the journal
  • SHARE

Let's create a brighter future

Join our team to work with renowned researchers, tackle groundbreaking
projects and contribute to meaningful scientific advancements

Join us!
Board of Trustees:
Member of:
Accredited with:
With the support of: