A novel tertiary squaramido-based reverse-turn module SQ is reported, and its conformational properties are evaluated. This module is easily incorporated into a α-peptide sequence by conventional solid-phase peptide synthesis. The structure characterization of the hybrid squaramido-peptide 4 is described, showing that the turn segment induces the formation of hairpin structures in water through the formation of both αSQ- and βSQ-turns.
L. Martínez, G. Martorell, A. Sampedro, P. Ballester, A. Costa, C. Rotger
Org. Lett. 2015, 17, 2980-2983
DOI:
Go to the journal
Join our team to work with renowned researchers, tackle groundbreaking
projects and contribute to meaningful scientific advancements