Gold-Catalyzed Intramolecular Reaction of Indoles with Alkynes: Facile Formation of Eight-Membered Rings and an Unexpected Allenylation

Cationic gold(I) complexes favor formation of six- and seven-membered rings by 6-endo-dig, 6-exo-dig, and 7-exo-dig cyclizations of alkynyl indoles, whereas indoloazocines are favored with AuCl3 as catalyst (see scheme). Allenes are also formed by a fragmentation process.

Gold-catalyzed intramolecular reaction of indoles with alkynes: Facile formation of eight-membered rings and an unexpected allenylation

C. Ferrer, A. M. Echavarren

Angew. Chem. Int. Ed. 2006, 45, 1105-1109
DOI: Go to the journal

Associated ICIQ research group/s:

Go to the journal
  • SHARE

Let's create a brighter future

Join our team to work with renowned researchers, tackle groundbreaking
projects and contribute to meaningful scientific advancements

Join us!
Board of Trustees:
Member of:
Accredited with:
With the support of: