Tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol (3), a highly efficient ligand for CuAAC reactions, has been immobilized onto Merrifield resins through different strategies. The SN2-supported Cu complex (8) is stable in water and under air; it is active at low catalyst loadings (1 mol%) and at low concentration (down to 0.125 M) in both aqueous and purely organic media. Resin 8 can be repeatedly reused in 1:1 MeOH-water for short reaction times (4 h) with the only precaution of Cu(I) reloading every five cycles.
E. Ozkal, S. Özçubukçu, C. Jimeno, M. A. Pericàs
Catal. Sci. Technol. 2012, 2, 195-200
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