Alkyne-azide click chemistry mediated carbanucleosides synthesis

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4′,4′-dihydroxymethyl-3′-deoxy carbanucleosides were synthesized based on a “click approach.” Various alkynes were introduced on a key azido intermediate by the “click” 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.