Synthesis of new antimalarial derivatives through a novel borylation reaction

Project description

Malaria is a parasitic disease that causes around half a million deaths annually worldwide. One of the main challenges in the fight against malaria is the development of resistance to antimalarial drugs by the parasites.

This project aims to synthesize new analogs of antimalarial drugs, such as artemisinin, through the functionalization of their carbon-hydrogen bonds. Obtaining these analogs with current methodologies is difficult or impossible, and a new borylation reaction will be developed for this purpose. This process will allow the use of carbon-hydrogen bonds to obtain organoboron compounds, which are essential for creating molecules that interfere with the biological function of the parasite.