Vidal’s research group in the cover of Chemistry - A European Journal
13th desembre 2011 -
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The front cover of Issue 50 of Chemistry – A European Journal shows an eruption of organic molecules. A similar ‘eruption’ of enantiomerically enriched amine, alcohol and α-amino acid derivatives that are valuable building blocks, intermediates or direct precursors for the synthesis of important pharmaceutical chiral compounds is described in the paper by Anton Vidal and co-workers.
One of the research lines in Anton Vidal’s research group is the synthesis of enantiomerically pure P-OP ligands (phosphine-phosphinites and phosphine-phosphites) and their application in asymmetric catalysis. (Chem. Rev. 2011, 111, 2119).In this Chem. Eur. J. paper, they use chiral cationic rhodium complexes of some of these P-OP ligands for the enantioselective hydrogenation reaction of a number of strategically devised alkenes, with high efficiency and high enantioselectivity.
In this way, they synthesise a range of enantiomerically enriched organic compounds that constitute advanced intermediates or direct precursors for the synthesis of relevant chiral pharmaceutical drugs. |
Enantioselective Access to Chiral Drugs by using Asymmetric Hydrogenation Catalyzed by Rh(POP) Complexes
Dr. Pablo Etayo, José Luis Núñez-Rico, Dr. Héctor Fernández-Pérez, Prof. Anton Vidal-Ferran
Chem. Eur. J., 2011, 17, 13978-13982
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