Pd-Catalyzed Intermolecular C-H Amidation: HOT article in Angew. Chem. Int. Ed.
8th febrer 2012 -
Following his studies on the intermolecular diamination reactions of alkenes through Pd catalysis, Kilian Muñiz and colleagues have now extended this C-N bond forming reaction to the direct palladium-catalysed intermolecular C-H amidation of several substrates.
They have identified NFSI (N-fluorobis(phenylsulfonyl)-imide), a commercially available oxidant, as both the oxidant and the nitrogen source for the Pd-catalyzed intermolecular sequence of the C-H activation and amidation of methyl groups.
They also provide mechanistic studies that suggest the involvement of a monomeric Pd (IV) intermediate also present in the C-N bond formation of their previous studies on the intermolecular diamination of alkenes.
This communication has been chosen as a “Hot Paper“ by the Editors of Angew. Chem. Int. Ed. for its importance in a rapidly evolving field of high current interest.
Read the paper here.
Dr. álvaro Iglesias, Prof. Dr. Rosana álvarez,Prof. Dr. ángel R. de Lera, Prof. Dr. Kilian Muñiz
DOI: 10.1002/anie.201108351
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